Theme 1
Each student will have to select and discuss a case study. The Case Study can involve a bacterial, viral, parasitic, or fungal infection or an intoxication caused by an infectious agent (such as Botulism or Staphylococcus aureus food poisoning, to name two).
The discussion should present information about the disease, including symptoms, pertinent diagnostic tests, laboratory (including Microbiology) and physical findings, treatments, and prognoses.
Please write the whole scenario on your discussion thread for referencing.
Case 10
A 22-year old woman presents at the walk-in health clinic with slight fever (38.5C), a complaint of frequent urination, burning on urination, vaginal discharge and a small lesion on the labia.
The woman reported that she was moderately sexually active and had three sexual partners in the past six months. Her last sexual contacts were about 7 days earlier. She had developed mild symptoms about 5 days earlier, beginning with a discharge from the vagina. She began having pain on urination about 3 days earlier.
Urine analysis revealed a pH of 8.2, some white cells and a few red blood cells. There was protein in the urine. A smear of the vaginal secretion showed a number of Gram-negative cocci.
1. What is your diagnosis here?
2. What clinical features are critical to your diagnosis?
3. What further actions must be taken?
Theme 2
Mutations in PDE6β gene result in a progressive loss of vision. Describe generation of a potential viral vector for treatment of this disease. What are the advantages and disadvantages of using this viral vector in gene therapy?
Theme 3
Clostridium difficile (C. diff.) is an opportunistic intestinal bacteria causes severe forms of diarrhea and bowel inflammatory disease. Search and discuss the treatment of C. diff. with Bacteriophages. Are there other types of bacterial infections treated with bacteriophages? What is the mode of action of this treatment option and what is the proposed route of delivery?
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