Hepatic abscess (HA) can be defined as an encapsulated collection of suppurative material within the liver parenchyma, which may be infected by bacterial, fungal, and/or parasitic micro-organisms. Since the majority of HAs in the Western world are infected with bacteria, pyogenic liver abscess will be the focus of this review.
In the early 1900s, the most common cause of HA was pylephlebitis secondary to appendicitis. In the late 1900s, biliary tract disease emerged as the most frequent culprit, and it remains the most common cause of HA today. More recently, there has been an increase in the incidence of HA arising in association with malignancies and their treatment, including HA from liver metastasis, and as complications of transarterial chemoembolization (TACE) or radiofrequency ablation (RFA).
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