Metabolic Syndrome, Obesity, IBS get help at
Metabolic Syndrome, Obesity, IBS
Susie G, is a 40 year old female with Metabolic Syndrome, Obesity, IBS (constipation predominant), Infertility, Fatigue, and PCOS. She has returned to you for a followup visit to discuss the results of her urinary Organic acid testing.
Organic Acids (only abnormal results are listed below, ALL OTHER RESULTS ARE NORMAL):
High Adipate and Suberate
High Beta-hydroxybutyrate
Low Hydroxymethylglutarate
High Xanthurenate Metabolic Syndrome, Obesity, IBS
High Formiminoglutamate
Low Vanilmandelate
Low 5-hydroxyindolacetate
High 8-hydroxy-2’-deoxyguanosine Metabolic Syndrome, Obesity, IBS
High Glucarate
High D-arabinitol
Based upon the 10 abnormal results listed above:
1. a. What pathways are impaired from the abnormal results? What nutritional supplements would be warranted for each imbalance (ie. if high in adipate, supplement with what nutrients? Do this for each of the 10 abnormal results)? 1 point
1. b. What other dietary adjustments would you make to help offset these organic acid imbalances (ie. list foods that are high in the specific nutrients listed from 1. a. in case Susie would rather get her nutrients from food than supplements)? 1 point
2. Pick 1 of the following pathways below: Metabolic Syndrome, Obesity, IBS
I. Catecholamine DEGRADATION Make sure to include MAO and COMT enzymes, cofactors, substrate and products. (Remember that catecholamine synthesis refers to the creation of dopamine, norepinephrine, and epinephrine while catecholamine DEGRADATION refers to the breakdown of dopamine, norepinephrine, and epinephrine into VMA and HVA).
OR
II. CNS Kynurenin pathway
2. a. DRAW OUT the pathway including substrates, products, enzymes, and cofactors from what you learned in the textbooks/PPTs. 1 point Metabolic Syndrome, Obesity, IBS
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